27 - 29 February, 2012, Meliá Berlin Hotel, Germany
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This workshop will introduce transporter modelling and its application
in drug development with a particular focus on DDI. The session will
include a tutorial of a newly developed static model for predicting
transporter-mediated rosuvastatin DDI.
Participants are encouraged to bring a laptop with Microsoft Excel for
this practical element.
Dr. James Clarke
GlaxoSmithKline PLC, UK
Cellular membranes function as highly efficient barriers against
the passive diffusion of most water-soluble nutrients and drug
molecules. Consequently, the movement of such molecules across
membranes is primarily mediated by membrane proteins that possess
various degrees of specificity and catalytic efficiency. In this
workshop, we will discuss cases where DT were utilized to potentially
enhance bioavailability or as therapeutic targets.
Dr. Imad Hanna
Drug Metabolism and Pharmacokinetics
Novartis Institutes for BioMedical Research, USA
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