09:30 Registration & coffee

11:30 Refreshment break & networking

10:00 – 13:00 Workshop B: Predicting transporter-mediated DDI: Static and PBPK modelling approaches

This workshop will introduce transporter modelling and its application in drug development with a particular focus on DDI. The session will include a tutorial of a newly developed static model for predicting transporter-mediated rosuvastatin DDI.

• Model selection and application
• Important parameters and missing data
• In vitro to in vivo extrapolation (IVIVE)
• Clinical relevance
• Hands-on tutorial with a static rosuvastatin DDI tool

Participants are encouraged to bring a laptop with Microsoft Excel for this practical element.

Dr. James Clarke
Senior Scientist
GlaxoSmithKline PLC, UK

13:00 Networking luncheon

15:30 Refreshment break & networking

14:00 – 17:00Workshop D: Drug and nutrient transport across biological barriers: Potential therapeutic applications and/or toxicological consequences

Cellular membranes function as highly efficient barriers against the passive diffusion of most water-soluble nutrients and drug molecules. Consequently, the movement of such molecules across membranes is primarily mediated by membrane proteins that possess various degrees of specificity and catalytic efficiency. In this workshop, we will discuss cases where DT were utilized to potentially enhance bioavailability or as therapeutic targets.

• Pro-drug strategies to enhance bioavailability via interaction with intestinal uptake transporters
• PK consequences of the inhibition of intestinal uptake transporters
• Renal uptake transporters as drug targets
• Challenges associated with the use of inhibitors of ABCtransport proteins to enhance efficacy of CNS-targeting drugs

Dr. Imad Hanna
Drug Metabolism and Pharmacokinetics
Novartis Institutes for BioMedical Research, USA

17:00 End of Workshop day