Conference Day Two: Wednesday 20th May 2009

8.45 Opening Remarks From Chairperson

Compound Collection Enhancement and Sourcing

9.15 Centralised Compound Operations And Sourcing Case Study

• Tracking of compounds/assays and the capture of in-house medicinal chemistry compounds for the compound library could be increased by 75%
• Reducing of powder consumption by approximately 90%
• Closing the gap between centralised and decentralised compound management approaches
• Ensure quick on site access to compounds without loosing the global accessibility
• Complementing automated stores with a low cost and highly flexible store concept

Marc Andreae
Laboratory Head, Compound Management
Novartis

10.00 Harnessing The Power Of Computational Chemistry To Decide Which Compounds To Test And Source

• How big does a compound library need to be?
• Using the power of computational chemistry to decide what molecules will be needed to compile a diverse, successful compound collection
• Knowing what’s in the library and the quality and volume of each compound

Jens Loesel
Computational Scientist
Pfizer Global R&D

Panel Discussion

11.15 Identifying, Selecting And Sourcing The Right Compounds For Optimal Library Enhancement And Successful Screening

• Describing what a diverse collection looks like
• The science of assembling successful, diverse screening subsets
• Addressing the need to reduce costs and make the most of the compound collection and existing resources
• Fulfilling your scientists needs by looking externally for compounds

All speakers and participants of the morning session are invited to join the discussion

12.00 Ensuring Maximum Quality Compounds By Implementing QC Data Follow-Up Process

• Ensuring compound integrity – hardware & QC strategy
• Implementing a semi-automated approach to processing QC data
• Benefits of compound QC

Dr. Reiner Dieden
Analytical & Physical Chemistry and Logistics Director
UCB

Integration Case Studies

13.30 Schering Plough: Organon Case Study: Integration Of Compound Libraries Post Merger

• Pre-merger discussion: Maintaining the integrity of the original libraries
• Short and long term IT solutions: Addressing the chemists immediate need for compounds, that must be registered centrally while harmonising different IT infrastructures
• Ensuring inventory visibility for scientists by both companies
• Aligning formats and workflows after compound retrieval from store
• Merging CM strategies: Discover recovery and archive store

Sylviane Komesli, PhD
Section Head, Molecular Pharmacology
Schering- Plough Corporation

14.45 SME Case Study: Improving Throughput Of Compound Handling, Quality Of Compounds And Flexibility Of Service

• Getting our in-house built software online and processing compound requests
• Evolving the software to automatically record purchasing and import of compounds
• Making compound information available in a company-wide database speed up everyday ‘non-lab’ activities
• Issues overcome in implementing a new liquid handler into our store to increase throughput to customers and allow for better plate format flexibility (96/384)
• Testing new diluted compounds with automated precipitate tester to ensure solubility
• QC initiatives: Random LC/MS tests to check stability and quality

Dr. Raffaella Brandi
Compound Management Project Leader
Siena Biotech

15.30 UCB Case Study: Re-Aligning IT Infrastructure Post-Merger And Building A Unified Screening Deck

• Challenges of merging existing databases and aligning the IT infrastructure
• Building a screening deck from two different compound collections
• Overcoming resource and physical space constraints

Dr. Reiner Dieden
Analytical & Physical Chemistry and Logistics Director
UCB

16.15 Closing Remarks From The Chairperson

[ Register Now ] · [ Next: Workshops ]