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Chirality in Drug Compounds
Reduce Lab Costs and Drive Efficiency through Effective use of Chiral Synthesis, Resolution and Crystallisation Techniques
December 1 - 2, 2008 · Cafe Royal, London, UK


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Speaker Bios

Professor-Timothy.-J.-Donohoe Professor Timothy J. Donohoe
Professor of Chemistry
University of Oxford

I am currently the Head of Organic Chemistry at the University of Oxford and a fellow of Magdalen College, Oxford.

Our research lies in the field of asymmetric synthesis and the application of stereoselective oxidation and reduction reactions to natural product synthesis. We have a burgeoning interest in the area of carbohydrates and the application of metathesis to the synthesis of heterocycles. My group currently consists of six post doctoral researchers, eleven D.Phil. students, four Part II students and one visiting student. A poster of the group's research can be found here.


Professor-Meir-Lahav Professor Meir Lahav
The Margaret Thatcher Professor of Chemistry Department of Materials and Interfaces
Weizmann Institute

  • Master degree at the hebrew University in Jerusalem.
  • Ph.D Weizmann institute of Science in the field of Solid-State Chemistry.1963-1967
  • Post doctoral studies at Harvard 1969-1971
  • Member of the Weizmann since than.
  • First Chair of the Department of Materials and Interfaces.
  • First director of the Minerva Center on Supra-Molecular Architectures.
  • Prizes:-
  • The V. Prelog Gold Medal in Stereochemistry. 1987. (with Leizerowitz)
  • The G. Aminoff Prize of the Swedish Academy of Science 2002.(with Leizerowitz)
  • The Chirality Medal 2006.

Dr-Mike-Song Dr Mike Song
Solid-State research Scientist, Organon
Part of Schering-Plough Corp.

Since 2002, Mike Song holds the position of research scientist in the department of Active Pharmaceutical Ingredients – Process Development, Schering-Plough Corporation, The Netherlands. He is responsible for solid-state issues addressing crystallisation, polymorph screening and salt selection. He has various collaborations with Lead Discovery, Pre-clinical and Clinical Developments and Production. Mike received his BEng in Chemical Engineering and PhD in crystallisation (under the supervision of Prof Roger Davey) from UMIST, UK.


Dr-Panagiotis-(Panos)-Karamertzanis Dr Panagiotis (Panos) Karamertzanis
Senior Post-Doctoral Associate, Department of Chemistry
University College London

Panos Karamertzanis graduated in Chemical Engineering (1998) from the National Technical University of Athens and received an MSc degree in Computational Fluid Dynamics from the Karman Institute in Brussels (2000). He received his PhD in Process Systems Engineering (2004) from Imperial College London, where he developed algorithms for the prediction of organic crystal structures without relying on experimental information. He then joined Prof. Price's group at the Department of Chemistry, UCL where he continues pursuing his research interests on the modelling of the organic solid state and the understanding of chiral separation by crystallisation.


Sharon-Bowden Sharon Bowden
Principal Crystallisation Scientist
AstraZeneca

The Development of a Reverse Classical Resolution

  • The theoretical approach taken to develop a reverse classical resolution (where the desired diastereomeric salt was retained in solution) for the manufacture of a chiral intermediate
  • The development of the process including selection of the resolving agent, solvent and process optimization

Biography

1995-1998 Warwick University BSc (Hons) Chemistry with Industrial Environmental Chemistry
Sept. 1998 - Sept. 2000 Zeneca/AstraZeneca, PR&D, Avlon Works, Bristol Process Chemist
Sept. 2000 – Sept. 2001 Warwick University MSc in Chemistry by Research
Feb. 2002 – Apr. 2004 AstraZeneca, Global Process R&D, Avlon Works, Bristol Process Chemist/Senior Process Chemist
Apr. 2004 – Apr. 2007 AstraZeneca, Global Process R&D, Avlon Works, Bristol Senior Crystallisation Specialist
Apr. 2007 - AstraZeneca, Global Process R&D, Avlon Works, Bristol Principal Crystallisation Specialist

As a Principal Crystallisation Specialist I am involved in the design, optimization and understanding of crystallisation processes for the manufacture of intermediates and active pharmaceutical ingredients for new and existing products.

Key Interest Areas

  • The crystallisation of enantiomers and diastereomers
  • Construction and use of ternary phase diagrams
  • The use of PAT for the development of crystallisation processes

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